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2.4.1 Errors in Genital Differentiation

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2.4.1 Errors in Genital Differentiation

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dc.contributor.author Marsh, Karen en_US
dc.contributor.author Bruce, Brendan en_US
dc.contributor.author La Barbera, Andrew R. en_US
dc.date.accessioned 2009-05-05T23:00:15Z en_US
dc.date.accessioned 2012-05-16T16:25:59Z
dc.date.available 2009-05-05T23:00:15Z en_US
dc.date.available 2012-05-16T16:25:59Z
dc.date.created 2008-08-15 en_US
dc.date.issued 2008-08-15 en_US
dc.identifier.uri http://hdl.handle.net/2374.UC/163 en_US
dc.description GOAL: To describe the control of sexual differentiation and describe the consequences of defective regulatory mechanisms. en_US
dc.description 2.4 Objective: To explain how genetic males and females with normally functioning gonads can have the genitalia and sex characteristic of the opposite sex. en_US
dc.description 2.4.1 Error in Genital Differentiation (Photo Gallery)

Male Pseudohermaphroditism
-What are the consequences of deficient androgen synthesis / action on differentiation and development of the male reproductive tract / sex accessory tissues?
-Deficiencies in which steroids biosynthetic enzymes would result in ambiguous external genitalia and male pseudohermaphroditism?
-What are the consequences of deficient testosterone in the fetus / at puberty?
-What is the most common cause of a deficiency of androgen action?
-What are the consequences of deficient androgen action in male and / female?
-What are the consequences during fetal development and at puberty of an inability to convert testosterone to dihydrotestosterone?

Female Pseudohermaphroditism
-Deficiencies of which steroid biosynthetic enzymes in the adrenal cortex result in production of androgens?
-What are the five most common deficiencies of steroids biosynthetic enzymes?
-What are the consequences of exposure to excess androgens on the reproductive tracts and external genitalia of females?
-What are the consequences of steroid biosynthetic enzyme deficiencies on water and electrolyte balance?

dc.language.iso en_US en
dc.subject p450c11 en
dc.subject p450c21 en
dc.subject.mesh Gonads en_US
dc.subject.mesh Steroids en_US
dc.subject.mesh Hormones en_US
dc.subject.mesh Reproduction en_US
dc.subject.mesh Steroid 11-beta-Hydroxylase en_US
dc.subject.mesh Sex Determination (Genetics) en_US
dc.subject.mesh Reproductive Physiological Phenomena en_US
dc.subject.mesh Gonadal Steroid Hormones en_US
dc.subject.mesh Steroid 21-Hydroxylase en_US
dc.subject.mesh Chromosomes en_US
dc.subject.mesh Testosterone 5-alpha-Reductase en_US
dc.subject.mesh Sex Differentiation en_US
dc.subject.mesh Androgens en_US
dc.subject.mesh Pseudohermaphroditism en_US
dc.title 2.4.1 Errors in Genital Differentiation en
dc.type Animation en
dc.publisher.digital University of Cincinnati. College of Medicine en
dc.publisher.OLrepository University of Cincinnati

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